My overall research goal is to create therapeutic interventions for viruses of public health concern by developing a detailed understanding of how the viruses interact with the host. My research has focused on the recently emerged and highly pathogenic coronaviruses: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Both viruses cause severe lung disease, are highly lethal and yet there are no FDA approved therapeutics that target them.
Important to understanding these diseases has been our development, characterization and utilization of mouse models of disease for both SARS-CoV and MERS-CoV. The rapid and successful development of these models has allowed us to unravel the cellular and physiological basis for disease of these viruses. In addition, the creation of these models has allowed for therapeutic development of vaccines, antibodies, small molecules, novel and repurposed drugs and other therapeutics. Critical to my research is the synergy of our in vitro and in vivo models of disease that allow us deep understandings of how these viruses work.
New recent work also focuses on Influenza virus, Norovirus and Rotavirus via in vitro yeast experiments described below. This new model uses yeast genetics platforms I used during my graduate school training synergizing with my current interest in viruses. Together we use yeast screens for functional genetic screens and high throughput drug screens to identify anti-viral interaction networks. We then model these networks in mammalian cells to identify proteins and pathways that effect virus replication as well as drugs that inhibit these same pathways, that are then tested using in vivo models of these pathogens. Combining our in vitro and in vivo systems identifies key proteins and nodes of regulation for further therapeutic targeting.ing interesting about your business here.
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